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Topical dexamethasone decelerates epithelial migration on the canine tympanic membrane
Jihyun Kim1, Taeho Oh1, Seulgi Bae1
1Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.
Veterinary Dermatology
|December 9, 2024
Summary
Topical dexamethasone slows epithelial migration on the tympanic membrane in dogs. This may impede ear canal debris removal, suggesting additional cleaning may be needed during treatment for otitis.
Area of Science:
- Veterinary Medicine
- Ophthalmology
- Cell Biology
Background:
- Epithelial migration (EM) is crucial for ear health.
- Glucocorticoids are common treatments for ear disorders.
- Their impact on tympanic membrane (TM) and external auditory canal (EAC) EM is not well understood.
Purpose of the Study:
- To investigate the effect of topical dexamethasone on EM on the canine TM.
- To test the hypothesis that dexamethasone decelerates TM EM.
Main Methods:
- Seven healthy dog ears were used.
- Ink drops tracked TM EM rates over 3 weeks using video-otoscopy.
- Compared EM rates between control and dexamethasone-treated ears.
Main Results:
- Topical dexamethasone reduced TM EM rate by 46.74% in dogs.
- This reduction was statistically significant (p < 0.05).
Conclusions:
- Topical dexamethasone decelerates EM on the canine TM.
- This may impair EAC debris clearance, potentially affecting the ear canal environment.
- Additional ear cleaning may be necessary when using dexamethasone for otitis in dogs.
