Genetic Testing: practical dos and don'ts for cats

Area of Science:

• Feline genetics and genomics.
• Application of DNA variant discovery in domestic cats.

Background:

• Numerous genetic variants are identified in domestic cats, with many linked to inherited diseases and phenotypic traits.
• Technological advancements enable large-panel genetic testing at a reduced cost, offering extensive DNA insights.

Purpose of the Study:

• To review available genetic tests for cats.
• To guide veterinarians in selecting appropriate testing laboratories.
• To provide advice on genetic testing counseling for cat owners and breeders.

Main Methods:

• Synthesis of scientific literature on feline DNA variant discovery and implications.
• Utilization of data from the Online Mendelian Inheritance in Animals (OMIA) database.
• Inclusion of expert recommendations based on feline genetics experience.

Main Results:

• Large-panel genetic testing provides numerous DNA results cost-effectively.
• Commercial genetic testing services vary, and selecting the best laboratory requires careful consideration.
• Interpretation of genetic data and test results can be complex, potentially leading to misinterpretations.

Conclusions:

• Genetic testing is essential for feline health monitoring, targeted therapy, and advancing scientific understanding.
• Veterinary practitioners, especially those with breeder clients, should integrate genetic testing into diagnostic and healthcare plans.
• Proper interpretation and counseling are vital to avoid misinterpretations and ensure effective breed and population management.