Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Levels of Organization01:09

Levels of Organization

145.0K
Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
145.0K
Studying the Cytoskeleton01:17

Studying the Cytoskeleton

10.5K
The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...
10.5K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.3K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.3K
Fixation and Sectioning01:03

Fixation and Sectioning

9.0K
Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens.
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
9.0K
Cryo-electron Microscopy01:28

Cryo-electron Microscopy

4.6K
Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
4.6K
Structural Organization of the Human Body: An Overview01:18

Structural Organization of the Human Body: An Overview

38.7K
It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
38.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trigger Factor in <i>Burkholderia pseudomallei</i> is essential for key virulence determinants, including host cell internalization, cytotoxicity, motility, and stress resistance.

Journal of bacteriology·2026
Same author

Structures of pentatricopeptide repeat proteins.

Acta crystallographica. Section F, Structural biology communications·2026
Same author

Probing the statistics of sequence-dependent DNA conformations in solution using SAXS.

Acta crystallographica. Section D, Structural biology·2026
Same author

GRASP: a modular toolkit for building synthetic pentatricopeptide repeat RNA-binding proteins.

Nucleic acids research·2025
Same author

Perspective on structure predictions of disorder.

Acta crystallographica. Section D, Structural biology·2025
Same author

NONO Maintains SREBP-Regulated Cholesterol Biosynthesis via RNA Binding in Neuroblastoma.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2025

Related Experiment Video

Updated: Apr 13, 2026

From Voxels to Knowledge: A Practical Guide to the Segmentation of Complex Electron Microscopy 3D-Data
12:08

From Voxels to Knowledge: A Practical Guide to the Segmentation of Complex Electron Microscopy 3D-Data

Published on: August 13, 2014

24.5K

Everyone is using biological structures, but how does one find the structure(s) one wants?

Charles S Bond1, Joel L Sussman2

  • 1University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.

Acta Crystallographica. Section D, Structural Biology
|December 9, 2024
PubMed
Summary

Finding specific scientific structures is challenging. This commentary suggests improvements for easier structure retrieval in scientific databases.

Keywords:
AlphaFold DBProtein Data BankUniProtbiological structuresstructural databases

More Related Videos

Array Tomography Workflow for the Targeted Acquisition of Volume Information using Scanning Electron Microscopy
09:47

Array Tomography Workflow for the Targeted Acquisition of Volume Information using Scanning Electron Microscopy

Published on: July 15, 2021

4.7K
A Rapid, Simple Workflow for Quantification of External Adult Drosophila Structures
08:55

A Rapid, Simple Workflow for Quantification of External Adult Drosophila Structures

Published on: November 8, 2024

365

Related Experiment Videos

Last Updated: Apr 13, 2026

From Voxels to Knowledge: A Practical Guide to the Segmentation of Complex Electron Microscopy 3D-Data
12:08

From Voxels to Knowledge: A Practical Guide to the Segmentation of Complex Electron Microscopy 3D-Data

Published on: August 13, 2014

24.5K
Array Tomography Workflow for the Targeted Acquisition of Volume Information using Scanning Electron Microscopy
09:47

Array Tomography Workflow for the Targeted Acquisition of Volume Information using Scanning Electron Microscopy

Published on: July 15, 2021

4.7K
A Rapid, Simple Workflow for Quantification of External Adult Drosophila Structures
08:55

A Rapid, Simple Workflow for Quantification of External Adult Drosophila Structures

Published on: November 8, 2024

365

Area of Science:

  • Structural Biology
  • Bioinformatics
  • Scientific Databases

Background:

  • Locating specific molecular structures within scientific literature and databases can be a complex and time-consuming process for researchers.
  • Current search functionalities may not adequately address the nuanced needs of users seeking particular structural information.

Purpose of the Study:

  • To comment on the difficulties encountered when searching for specific scientific structures.
  • To propose actionable strategies for enhancing the accessibility and searchability of structural data.

Main Methods:

  • Qualitative commentary and analysis of existing search methodologies.
  • Review of user-based challenges in information retrieval for structural biology.

Main Results:

  • The ease of finding a structure of interest varies significantly, often proving more difficult than anticipated.
  • Identified limitations in current search tools and database architectures hinder efficient structure discovery.

Conclusions:

  • Addressing the challenges in structure retrieval requires a multi-faceted approach involving database optimization and improved search algorithms.
  • Implementing suggested improvements can significantly enhance the efficiency of scientific research by facilitating quicker access to crucial structural data.