Interpretation of testicular biopsy for infertility: a practical guide

Testicular biopsies are often performed in men with unexplained infertility and azoospermia to ascertain the status of spermatogenesis. Testicular pathology is one of the primary causes of male infertility. However, infrequent exposure among pathologists and a lack of uniform reporting terminology pose diagnostic challenges and variability in interpretation. These issues may lead to inaccurate evaluations, potentially impacting clinical management. The goal of this review is to offer a straightforward, practical approach to interpreting testicular biopsies, thereby assisting pathologists who handle such rare samples. Accurate interpretation of testicular biopsy for infertility plays a crucial role in management of infertile men. In this review, we present a practical guide for reporting testicular biopsies.