Perirenal Adipose Tissue: Clinical Implication and Therapeutic Interventions
Seyed Amirhossein Fazeli1,2,3, Sina Nourollahi4, Amirhesam Alirezaei1
1Clinical Research and Development Center, Shahid Modarres Educational Hospital, Division of Nephrology, Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Indian Journal of Nephrology
|December 9, 2024
Summary
Perirenal adipose tissue (PRAT) plays a key role in body homeostasis and disease risk. Understanding therapeutic effects on PRAT size and metabolism is crucial for treating related conditions.
Area of Science:
- Physiology
- Endocrinology
- Nephrology
Background:
- Perirenal adipose tissue (PRAT) is vital for local and systemic homeostasis, influencing renal and cardiovascular functions.
- PRAT is recognized as a significant risk factor in cardiovascular diseases, renal disorders, malignancies, and other pathologies.
- Understanding therapeutic interventions' impact on PRAT is essential for managing associated health risks.
Purpose of the Study:
- To review existing literature on perirenal adipose tissue (PRAT).
- To summarize the effects of various therapeutic interventions on PRAT.
- To highlight the need for focused research on PRAT in disease and treatment.
Main Methods:
- Systematic review of scientific papers focusing on adipose tissue and therapeutic effects.
- Extraction of data specifically pertaining to perirenal adipose tissue (PRAT) from broader studies.
- Synthesis of findings regarding changes in PRAT mass, metabolism, and drug accumulation.
Main Results:
- Therapeutic interventions demonstrate varied effects on PRAT, including alterations in mass and metabolism.
- Drug residue accumulation within PRAT has been observed.
- Current research often overlooks PRAT as a distinct entity, analyzing overall adipose tissue instead.
Conclusions:
- Further research is needed to fully elucidate the role of PRAT in health and disease.
- PRAT should be considered a specific target for therapeutic interventions and research.
- Focused studies on PRAT can lead to improved management of metabolic and cardiovascular diseases.
Related Concept Videos
01:21External Anatomy of the Kidney
768
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
768
01:29Cholesterol: Significance and Regulation
504
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
504