Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Organization01:24

Protein Organization

6.2K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
6.2K
Ionic Crystal Structures02:42

Ionic Crystal Structures

14.1K
Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
14.1K
Protein Folding01:22

Protein Folding

117.3K
Overview
117.3K
Structures of Solids02:22

Structures of Solids

14.0K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
14.0K
Protein and Protein Structure02:15

Protein and Protein Structure

78.5K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
78.5K
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

5.7K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ChatGPT-5.4 in health education: inter-generation stability and persistent readability challenges.

Frontiers in public health·2026
Same author

ROS produced in mitochondria entrapped by self-assembly peptide fibers for target therapy of glioma.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

In Silicon Deciphering Atomic-Scale Structural Units in Peptide Glass.

Angewandte Chemie (International ed. in English)·2026
Same author

Bacterial Systems as a Precision Delivery Platform of Therapeutic Peptides for Cancer Therapy.

Polymer science & technology (Washington, D.C.)·2026
Same author

The association between retirement and 24-hour movement behaviour composition in older adults.

BMC public health·2026
Same author

Engineered Bacteria as Living Materials for Oral Delivery of Peptide Drugs.

ACS applied materials & interfaces·2026

Related Experiment Video

Updated: Jun 5, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

12.9K

Hierarchically oriented organization in supramolecular peptide crystals.

Chengqian Yuan1, Wei Ji2, Ruirui Xing1

  • 1State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China.

Protein and Peptide Letters
|December 9, 2024
PubMed
Summary

This review explores hierarchical self-assembly in peptides, proposing a new concept of hierarchically oriented organization for self-assembling peptide crystals. This mechanism differs from traditional crystallization, offering insights for designing functional biomolecular systems.

More Related Videos

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

8.1K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K

Related Experiment Videos

Last Updated: Jun 5, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

12.9K
Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

8.1K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K

Area of Science:

  • Biomolecular self-assembly
  • Crystallization mechanisms
  • Supramolecular chemistry

Background:

  • Hierarchical self-assembly and crystallization are fundamental to natural structures and biological functions.
  • Biological multiscale hierarchical structures inspire research into peptide and amino acid self-assembly.
  • Understanding these mechanisms is key for fabricating complex functional systems with molecular alignment.

Purpose of the Study:

  • To review examples of hierarchically oriented organization in peptide self-assembly.
  • To discuss the thermodynamic and kinetic mechanisms driving this specific hierarchical organization.
  • To introduce and define the concept of hierarchically oriented organization for self-assembling peptide crystals.

Main Methods:

  • Literature review of typical examples of hierarchically oriented organization in peptide self-assembly.
  • Analysis of thermodynamic and kinetic factors influencing hierarchical self-assembly and crystallization.
  • Conceptual proposal of hierarchically oriented organization as a distinct mechanism.

Main Results:

  • Summarized typical examples of hierarchically oriented organization in peptide self-assembly.
  • Identified key thermodynamic and kinetic mechanisms governing this organization.
  • Proposed a novel concept: hierarchically oriented organization for self-assembling peptide crystals, distinct from Ostwald ripening.

Conclusions:

  • Hierarchically oriented organization offers a new perspective on peptide crystallization.
  • This mechanism is crucial for understanding and designing advanced functional biomolecular systems.
  • Future research should focus on mechanistic understanding and versatile applications of this organizational principle.