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Updated: May 5, 2026
Pre-clinical Model of Cardiac Donation after Circulatory Death
Published on: August 2, 2019
Adult cardiac transplantation utilizing donors after circulatory death
Tanisha Rajah1, David Blitzer2, Scott Silvestry3
1Birmingham Medical School, University of Birmingham, Birmingham, UK.
Insights
Donation after circulatory death (DCD) heart transplants increase organ availability but require defined best practices. Standardization of key elements like "stand-off" time and warm ischemic time (WIT) is crucial for future use.
Area of Science:
- Cardiology
- Transplantation Medicine
- Surgical Innovation
Background:
- Donation after circulatory death (DCD) heart transplantation offers a solution to organ shortages.
- Increased global heart transplant volumes are attributed to the adoption of DCD protocols.
Purpose of the Study:
- To highlight the opportunities and challenges associated with DCD heart transplantation.
- To emphasize the need for defining long-term outcomes and best practices for DCD heart donation.
Main Methods:
- Review of current DCD heart transplantation practices.
- Analysis of factors influencing the expansion of DCD donation programs.
Main Results:
- DCD heart donation has successfully increased the number of available organs for transplantation worldwide.
- Significant resource allocation, coordination, and training are necessary for expanding DCD donation.
Conclusions:
- Further research is required to establish long-term outcomes and optimal practices for DCD heart transplantation.
- Standardization of critical parameters, including "stand-off" time, warm ischemic time (WIT), and perfusate composition, is essential for advancing DCD heart donation.
Abstract:
Donation after circulatory death (DCD) presents both opportunities and challenges in the realm of heart transplantation. Its emergence holds promise for narrowing the gap between patients in need of organs and the available donor pool. The rapid emergence of DCD use has allowed heart transplant volume to increase worldwide. Long-term outcomes and best practices remain to be defined and are important considerations in the wider use of these techniques in a broad selection of patients to understand best use and practice moving forward. Expanding DCD donation entails substantial resource allocation, coordination efforts, and training initiatives. Moving forward, standardization is imperative, particularly in aspects such as "stand-off" time, warm ischemic time (WIT), and perfusate composition.
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