Related Experiment Video
Updated: Jul 18, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Distal femur osteosarcoma in a seven-year-old: a case report on acute symptom presentation
Neveen Shalalfa1, Saleh Wajeeh2, Zaina Sheeb1
1Palestine Polytechnic University, Hebron, Palestine.
Introduction And Importance:
Osteosarcoma is an exceptionally serious, uncommon disease in children with morbidity, mortality, and psychological burdens.
Case Presentation:
In this report, the authors present the case of a previously healthy 7-year-old girl who exhibited continuous, painful limping. Plain imaging and a MRI scan revealed the presence of a lytic lesion in the femur on the left side. The diagnosis of osteosarcoma was confirmed. There was no significant familial history of cancer. The girl and her family underwent the operation and chemotherapy, received follow-up and support for a year, and both the patient and the medical team expressed a lot of satisfaction.
Clinical Discussion:
The survival and prognosis from osteosarcoma in the literature was 59% for all patients at a median follow-up up 54 months, current treatment of osteosarcoma involves chemotherapy and limb surgery, with (60-80)% of patients in remission after 5 years.
Conclusion:
This case emphasizes the importance of promptly considering osteosarcoma in a child when the clinical presentation and medical imaging align with the diagnosis.
Related Concept Videos
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Rocky Mountain Spotted Fever

