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Updated: Jun 5, 2025

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction
Published on: April 14, 2022
Myasthenia gravis: The evolving therapeutic landscape
Gil I Wolfe1, Jonathan E Hanson1, Nicholas J Silvestri1
1From the Dept. of Neurology, Jacobs School of Medicine and Biomedical Sciences, Univ. at Buffalo, State University of New York, Buffalo, NY, USA.
Abstract:
Pharmacological options in the management of generalized myasthenia gravis (gMG) have expanded rapidly in the last 7 years. There are now several complement inhibitors and neonatal Fc receptor antagonists on the market in many countries for patient management, following the successful completion of Phase 3 studies. In open-label extensions, these agents have proven to be effective over the longer term extending several years, with benefits such as reduction of corticosteroid requirements being observed. In the communication below, we will briefly summarize recent pharmacologic advancements in the management of gMG and outline how these agents are currently being used and may be used in the future.
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