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Related Experiment Videos

Syncope with prolonged QT interval.

J P Frank, D Z Friedberg

    American Journal of Diseases of Children (1960)
    |March 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Propranolol hydrochloride effectively treated syncope in children with prolonged QT intervals. While symptoms resolved, electrocardiogram abnormalities persisted, indicating ongoing cardiac risk.

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    Area of Science:

    • Pediatric Cardiology
    • Clinical Electrophysiology
    • Neurology

    Background:

    • Syncope in children can be linked to cardiac conditions, including prolonged QT interval.
    • Long QT syndrome (LQTS) poses a risk for sudden cardiac death.
    • Diagnostic workup for pediatric syncope requires thorough cardiac and neurologic evaluation.

    Observation:

    • Four pediatric patients presented with syncope and electrocardiogram findings of a prolonged QT interval.
    • Neurologic examinations and studies were unremarkable in all cases.
    • Associated conditions included deaf mutism in one patient and a family history of sudden death and prolonged QT interval in another. Two patients experienced ventricular arrhythmias during hospitalization.

    Findings:

    • Treatment with propranolol hydrochloride successfully eliminated syncopal episodes in all four children.

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  • Electrocardiogram abnormalities, specifically the prolonged QT interval, persisted despite clinical improvement.
  • This suggests propranolol addresses the symptomatic manifestation of syncope but not the underlying electrical instability.

    • Implications:

    • Propranolol hydrochloride is a viable therapeutic option for managing syncope associated with prolonged QT interval in pediatric patients.
    • Continuous cardiac monitoring and risk stratification remain crucial due to persistent ECG abnormalities.
    • Further research into the long-term effects and underlying mechanisms is warranted for comprehensive management of pediatric LQTS.