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Craniosynostosis-4 with Heterozygous Mutation in the ERF Gene: A Case Report
Ragavandran Ranganathan1, Sharada Reddy Jampanapalli1, Divya Barathi2
1Department of Pedodontics and Preventive Dentistry, Govt. Dental College & Hospital, Hyderabad, Telangana, India.
Craniosynostosis-4, a genetic condition caused by an ERF gene mutation, affects skull growth and presents with dental issues. Early dental interventions are crucial for managing complications in affected children.
Area of Science:
- Genetics
- Pediatric Dentistry
- Craniofacial Abnormalities
Background:
- Craniosynostosis (CS) is the premature fusion of cranial sutures, leading to abnormal head shape and potential brain growth restriction.
- It affects 1 in 2,000-2,500 children and can be syndromic or nonsyndromic, with sagittal suture involvement being most common.
- CS can result from genetic mutations or secondary factors during pregnancy.
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