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Related Concept Videos

Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
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Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis00:59

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

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Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
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Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

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Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
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Pharmacovigilance01:19

Pharmacovigilance

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
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Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

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Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
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Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters00:54

Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters

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The noncompartmental approach is a widely used method in pharmacokinetics to assess drugs' behaviors in the body. It considers several factors, including clearance, bioavailability, and total volume of distribution.
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Related Experiment Video

Updated: Jun 5, 2025

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump
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Non-dispensed prescriptions - A nationwide descriptive study.

Heini Kari1, Fredriikka Nurminen1, Hanna Rättö1,2

  • 1Research Unit, The Social Insurance Institution of Finland (Kela), Helsinki, Finland.

Exploratory Research in Clinical and Social Pharmacy
|December 9, 2024
PubMed
Summary

Medication non-adherence is a significant issue, with 13.3% of prescriptions never filled. This study highlights variations in non-dispensed prescriptions across patient and medicine groups, impacting healthcare outcomes.

Keywords:
Medication adherenceNon-dispensed prescriptionsOutpatient carePharmacoepidemiologyPrescribing

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Area of Science:

  • Health Services Research
  • Pharmaceutical Sciences
  • Public Health

Background:

  • Medication non-adherence leads to poor health outcomes, increased mortality, and higher healthcare expenses.
  • Understanding prescription non-dispense rates is crucial for improving patient care and resource allocation.

Purpose of the Study:

  • To quantify the national prevalence of non-dispensed prescriptions in Finland.
  • To identify patient and medication subgroups with higher rates of non-dispensed prescriptions.

Main Methods:

  • Nationwide retrospective register-based study utilizing Finnish prescription data from 2020.
  • Analysis of prescriptions prescribed in 2020 and dispensed between 2020-2022.
  • Inclusion of patient demographics (age, sex, income) and medication details, analyzed using distributions and odds ratios.

Main Results:

  • 13.3% of 26 million prescriptions were never dispensed, affecting 43.3% of patients.
  • Non-dispensed prescription rates varied by demographics and therapeutic area, with dermatologicals (20.2%) and 'other nervous system drugs' (38%) showing high rates.
  • Commonly non-dispensed medications included paracetamol, ibuprofen, and salbutamol.

Conclusions:

  • Significant variation exists in non-dispensed prescription rates across various subgroups.
  • Healthcare professionals should focus on reducing unnecessary prescribing and enhancing medication adherence for improved patient safety and efficacy.