Recurrent Corneal Erosion Induced by 1% 5-Fluorouracil Solution

Cytotoxic anticancer drug solution eye drops can hinder the cell division of corneal basal cell division and corneal limbal epithelial stem cell migration. We discuss a case involving recurrent corneal epithelial erosions induced by 1% 5-fluorouracil (5-FU) solution eye drops. A 68-year-old male with conjunctival papilloma on his left eye underwent recurrences three times and additional tumor excision. He was prescribed 1% 5-FU solution eye drops two times a day without drug holidays and experienced recurrent corneal epithelial erosion. This report highlights the necessity of drug holidays for patients receiving cytotoxic anticancer drug solution eye drops.