Recurrent Corneal Erosion Induced by 1% 5-Fluorouracil Solution

Area of Science:

• Ophthalmology
• Oncology
• Cell Biology

Background:

• Cytotoxic anticancer drugs, such as 5-fluorouracil (5-FU), are used in treating various ocular conditions.
• These drugs can interfere with cell division and migration, potentially affecting ocular surface tissues.

Observation:

• A case study involving a 68-year-old male with conjunctival papilloma treated with 1% 5-FU eye drops is presented.
• The patient experienced recurrent corneal epithelial erosions despite multiple tumor excisions and continuous 5-FU treatment.

Findings:

• Continuous use of 1% 5-FU eye drops without breaks was associated with recurrent corneal epithelial erosion.
• The cytotoxic effects of 5-FU hindered corneal basal cell division and limbal stem cell migration.

Implications:

• This case underscores the critical importance of incorporating drug holidays when prescribing cytotoxic eye drops.
• Implementing scheduled breaks may mitigate the risk of severe ocular surface toxicity and promote healing.