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The Enigma of Idiopathic Multicentric Castleman Disease: An Elusive Diagnosis

Jessica Ohemeng-Dapaah1, Afoma Onyechi1, Ayesha Kang1

  • 1Internal Medicine, Sisters of Saint Mary (SSM) Health St. Mary's Hospital, St. Louis, USA.

Cureus
|December 9, 2024
PubMed

Insights

Idiopathic multicentric Castleman disease (iMCD) is a rare disorder causing systemic inflammation and lymphadenopathy. Early diagnosis and IL-6 blockade are crucial for managing iMCD, though this case highlights diagnostic challenges and treatment complexities.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Castleman disease (CD) is a rare lymphoproliferative disorder with diverse presentations.
  • Idiopathic multicentric Castleman disease (iMCD) involves generalized lymphadenopathy, systemic inflammation, and a dangerous cytokine storm.
  • Diagnosis of CD can be challenging due to overlapping symptoms with other conditions.

Keywords:
castleman diseasehistopathologyinflammationlymphadenopathymulticentricpancytopeniaplasmacytosissiltuximab

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