Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermosensation01:43

Thermosensation

30.3K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
30.3K
Thermoregulation01:26

Thermoregulation

899
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
899
Body Temperature01:25

Body Temperature

911
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
911
Mechanism of heat transfer01:19

Mechanism of heat transfer

1.2K
Understanding heat transfer mechanisms is essential for understanding how our bodies maintain balance in different environmental conditions. When the environment is thermoneutral, the body is in a state of balance, neither using nor releasing energy to maintain its core temperature. However, when the environment is not thermoneutral, the body employs four heat transfer mechanisms to maintain homeostasis: conduction, convection, evaporation, and radiation. These mechanisms facilitate heat...
1.2K
Somatosensation01:33

Somatosensation

36.4K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
36.4K
What is Homeostasis?01:16

What is Homeostasis?

35.4K
Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
35.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Roadmap to Navigate the Future of Neural Engineering.

Journal of neural engineering·2026
Same author

Somatosensory input drives membrane potential dynamics in motor cortex during voluntary limb movement.

PLoS biology·2026
Same author

The neuronal circuits and cellular encoding of thermosensation.

Nature reviews. Neuroscience·2025
Same author

The cellular representation of temperature across the somatosensory thalamus.

bioRxiv : the preprint server for biology·2024
Same author

Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.

Nature communications·2024
Same author

Eleven strategies for making reproducible research and open science training the norm at research institutions.

eLife·2023
Same journal

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026
Same journal

Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas.

bioRxiv : the preprint server for biology·2026
Same journal

Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles.

bioRxiv : the preprint server for biology·2026
Same journal

Integrative Transfer Network: Deep Transfer Learning Across Populations and Prediction Targets.

bioRxiv : the preprint server for biology·2026
Same journal

Confidence-supported label-free metabolic imaging with FPhaS phase autofluorescence microscopy.

bioRxiv : the preprint server for biology·2026
Same journal

Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2025

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

14.7K

Bidirectionally responsive thermoreceptors encode cool and warm.

Phillip Bokiniec, Clarissa J Whitmire, James F A Poulet

    Biorxiv : the Preprint Server for Biology
    |December 9, 2024
    PubMed
    Summary
    This summary is machine-generated.

    This study reveals how thermoreceptors detect everyday cool and warm temperatures. The cool-sensitive TRPM8 channel explains how these receptors signal both sensations.

    More Related Videos

    Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat
    09:43

    Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat

    Published on: December 11, 2017

    6.9K
    Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
    11:08

    Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis

    Published on: June 3, 2016

    7.2K

    Related Experiment Videos

    Last Updated: Jun 5, 2025

    A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
    08:35

    A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

    Published on: March 17, 2015

    14.7K
    Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat
    09:43

    Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat

    Published on: December 11, 2017

    6.9K
    Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
    11:08

    Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis

    Published on: June 3, 2016

    7.2K

    Area of Science:

    • Neuroscience
    • Sensory Biology
    • Thermoreception

    Background:

    • Thermal sensation relies on primary afferent thermoreceptors.
    • Encoding of noxious temperatures is well-studied, but innocuous temperature encoding remains unclear.

    Purpose of the Study:

    • To investigate how thermoreceptors encode innocuous cool and warm temperatures.
    • To elucidate the peripheral mechanisms of thermal sensation.

    Main Methods:

    • In vivo two-photon calcium imaging in mouse dorsal root ganglia.
    • In vivo pharmacology and computational modeling.

    Main Results:

    • The majority of thermoreceptors exhibit bidirectional responses, enhancing to cool and suppressing to warm.
    • Conductance changes in the TRPM8 channel sufficiently explain these bidirectional responses.

    Conclusions:

    • This research clarifies fundamental principles of peripheral innocuous temperature encoding.
    • The same thermoreceptor population appears to mediate distinct cool and warm sensations.