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Reporting Bone Cytopathology-A Proposal Based on a Single Tertiary Centre Experience.
Jan Köster1,2, Camila Bedeschi Rego De Mattos3, Henryk A Domanski2,4
1Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Summary
Fine-needle aspiration cytology (FNAC) of bone lesions is a sensitive and specific tool. This study evaluated its diagnostic utility and proposed a standardized reporting system for bone cytopathology, showing high accuracy across tumor types.
Area of Science:
- Cytopathology
- Bone pathology
- Oncology
Background:
- Fine-needle aspiration cytology (FNAC) is valuable for bone lesions but lacks standardization.
- Developing a standardized reporting system is crucial for consistent diagnosis.
Purpose of the Study:
- Evaluate the diagnostic utility of FNAC for bone lesions.
- Propose and test a standardized reporting system for bone cytopathology.
Main Methods:
- Retrospective analysis of 721 bone lesion FNAC cases (2015-2023).
- Assessed diagnostic performance using sensitivity, specificity, and accuracy.
- Categorized diagnoses and calculated the risk of malignancy (ROM).
Main Results:
- FNAC demonstrated 89% sensitivity and 99% specificity in differentiating benign and malignant lesions.
- Overall diagnostic accuracy was 65%, varying by lesion type.
- Risk of malignancy ranged from 6.7% (Benign) to 100% (Malignant).
Conclusions:
- FNAC of bone lesions is a highly sensitive and specific diagnostic method.
- The study offers insights for a standardized bone cytopathology reporting system.
- Standardization can improve diagnostic accuracy and patient management.
