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Prospective evaluation of serum and peritoneal fluid markers as indicators of postoperative complications in patients with enteric anastomosis

  • 0From the Surgical Clinic, Clinical Hospital Center Kosovska Mitrovica, Kosovska Mitrovica, Serbia.
Annals of Saudi Medicine +

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December 9, 2024

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December 9, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Monitoring lactate, albumin, and lactate dehydrogenase (LDH) in drain fluid after colorectal surgery can help predict complications. Higher lactate and albumin levels may indicate increased risk of anastomotic dehiscence and general postoperative issues.

Area Of Science

  • Biochemistry
  • Surgical Oncology
  • Clinical Diagnostics

Background

  • Postoperative complications following colorectal cancer surgery significantly increase patient morbidity and mortality.
  • Enteral anastomosis is a critical surgical step where complications like dehiscence can occur.
  • Identifying reliable biochemical markers for early detection of these complications is crucial.

Purpose Of The Study

  • To investigate the predictive role of serum and peritoneal fluid biochemical markers for postoperative complications in patients undergoing enteral anastomosis.
  • To assess the association between specific markers and the development of anastomotic dehiscence and general postoperative complications.

Main Methods

  • Prospective study involving 52 patients undergoing colorectal surgery with anastomosis or Hartmann's resection.
  • Monitoring of lactate, albumin, lactate dehydrogenase (LDH), and IgA antibodies in drain fluid.
  • Spearman's correlation coefficient was used to analyze associations between variables.

Main Results

  • Elevated lactate levels in drain fluid on postoperative day 3 were associated with non-dehiscence.
  • Higher albumin concentration on postoperative day 3 correlated with dehiscence, while day 7 levels correlated with non-dehiscence.
  • Significant differences in lactate and albumin concentrations were observed concerning general postoperative complications.

Conclusions

  • Drain fluid concentrations of lactate, albumin, and LDH on postoperative days 3 and 5 show significant differences related to complication development.
  • Monitoring these biochemical markers may aid in the early identification of patients at risk for anastomotic dehiscence and other postoperative complications.
  • Further research is warranted, considering study limitations such as sample size and the absence of a control group.