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Updated: Jun 5, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Copper-Catalyzed One-Pot Protocol for Reductive N-Arylation of Nitroarenes with (Hetero)aryl Chlorides in Water
Peng Hong1, Lifang Wang1, Xinhai Zhu2
1School of Chemical Engineering and Technology, Guangdong Engineering Technology Research Center for Platform Chemicals from Marine Biomass and Their Functionalization, Sun Yat-sen University, Zhuhai 519082, P. R. China.
Abstract:
A novel protocol for the Cu-catalyzed reductive N-arylation of nitroarenes with (hetero)aryl chlorides in water has been realized. Combining N-(9H-carbazol-9-yl)-6-hydroxypicolinamide (L2) with oxalohydrazide is vital to realize the method at 90 °C with a loading of 5 mol % of Cu2O/L2. Various nitroarenes and aryl chlorides have been successfully coupled in good to excellent isolated yields. Further, two diarylamine-containing key intermediates, 3f and 4u, have been smoothly synthesized on a gram scale using this method.
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