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Widened E point septal separation in a normal pediatric population.

L Matzer, X Cortada, P Ferrer

    Chest
    |January 1, 1985
    PubMed
    Summary
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    E point septal separation (EPSS) measurements reveal distinct age and gender patterns in normal individuals. Male adolescents exhibit wider EPSS than adult males and females, suggesting a potential link to androgen effects.

    Area of Science:

    • Cardiology
    • Echocardiography
    • Human Physiology

    Background:

    • E point septal separation (EPSS) is an echocardiographic measurement reflecting left ventricular diastolic function.
    • Understanding the normal age and gender distribution of EPSS is crucial for accurate clinical interpretation.

    Purpose of the Study:

    • To investigate the age and gender-specific distribution of E point septal separation (EPSS) in a normal population.
    • To identify potential factors influencing EPSS variations across different age groups and sexes.

    Main Methods:

    • M-mode echocardiograms were analyzed from 121 healthy subjects.
    • Subjects ranged in age from four months to 82 years.
    • EPSS measurements were correlated with age and gender.

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    Main Results:

    • A significant age-related difference in EPSS was observed: 3.0 +/- 2.6 mm in individuals under 20 years versus 1.4 +/- 1.8 mm in those over 20 years (p < .001).
    • In females, EPSS showed minimal variation with age.
    • In males, EPSS peaked between ages 15-19 and was significantly wider than in females within the 10-19 age group.

    Conclusions:

    • E point septal separation (EPSS) demonstrates a unique age and gender distribution, being wider in male adolescents compared to adults.
    • The observed pattern suggests a potential influence of androgens on myocardial properties during male adolescence.
    • Further research is warranted to elucidate the precise mechanisms behind these findings.