Related Experiment Video
Updated: Jun 5, 2025

Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates
Published on: April 22, 2019
Collagen Matrix Versus Subepithelial Connective Tissue for Recession Coverage: A Systematic Review
Alessandro Zangani1, Miriana Gualtieri1, Alessia Pardo1
1Dentistry and Maxillofacial Surgery Unit, Department of Surgery, Dentistry, Paediatrics and Gynaecology (DIPSCOMI), University of Verona, Verona, Italy.
Collagen matrix (CMX) and subepithelial connective tissue graft (SCTG) show comparable gingival recession coverage. However, SCTG offers superior recession reduction and keratinized tissue width, while CMX provides faster procedures and increased tissue thickness.
Area of Science:
- Periodontology
- Regenerative Dentistry
- Oral Surgery
Background:
- Gingival recession affects numerous patients, leading to aesthetic concerns and potential root surface issues.
- Surgical coverage of gingival recession is a common dental procedure.
- Collagen matrix (CMX) has emerged as an alternative material for root coverage procedures.
Purpose of the Study:
- To compare the efficacy of collagen matrix (CMX) versus subepithelial connective tissue graft (SCTG) for gingival recession coverage (RC).
- To evaluate outcomes including percentage of recession coverage, recession reduction, and keratinized tissue dimensions.
Main Methods:
- A systematic review and meta-analysis of randomized controlled trials was conducted.
- Studies compared CMX versus SCTG or CMX versus no grafting for Class I recession.
- Risk of bias assessment and quantitative analysis were performed.
Main Results:
- No significant difference in %RC between CMX and SCTG (p=0.37).
- SCTG showed significantly greater recession reduction (p=0.02) and keratinized tissue width (p=0.03).
- CMX demonstrated significantly better %RC (p=0.003) and keratinized tissue thickness (p<0.0001) compared to no grafting, with shorter intervention times (p<0.0001).
Conclusions:
- CMX is a viable option for gingival recession coverage, particularly when increased keratinized tissue thickness and reduced surgical time are desired.
- The choice between CMX and SCTG may depend on specific patient and clinical factors.
- Further research may explore long-term outcomes and patient-reported benefits.
Related Concept Videos
Extracellular Matrix
Introduction to Connective Tissues
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Connective Tissue Fibers and Ground Substance
The Extracellular Matrix
Reticular Dermis
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

