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Updated: Jun 5, 2025
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Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
Published on: May 17, 2014
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mTORC1 and mTORC2 Levels in Patients with Psoriasis
İlayda Esna Gülsunay1, İlknur Altunay1, Tuğba Kum2
1University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, Dermatology Department, Seyrantepe, İstanbul, Turkey.
Dermatology Practical & Conceptual
|December 9, 2024
Summary
Psoriasis patients show lower serum levels of mammalian target of rapamycin (mTOR)C1 and mTORC2. These findings suggest mTOR pathway involvement in psoriasis pathogenesis and potential therapeutic targets.
Area of Science:
- Dermatology
- Molecular Biology
- Cell Signaling
Background:
- The mammalian target of rapamycin (mTOR) pathway is increasingly recognized for its role in psoriasis development.
- mTOR is a key regulator of cellular metabolism, making it a significant focus in psoriasis research.
Purpose of the Study:
- To investigate the significance of the mTOR pathway in the pathogenesis of plaque psoriasis.
- To compare mTORC1 and mTORC2 levels in psoriasis patients versus healthy controls.
Main Methods:
- A case-control study involving 40 plaque psoriasis patients and 40 healthy volunteers.
- Fasting serum levels of mTORC1 and mTORC2 were quantified using enzyme-linked immunosorbent assay (ELISA).
Main Results:
- Patients with plaque psoriasis exhibited significantly lower serum levels of both mTORC1 and mTORC2 compared to controls (P = 0.001).
- A strong positive correlation was observed between serum mTORC1 and serum mTORC2 levels in psoriasis patients (p=0.001, r=0.826).
Conclusions:
- Reduced serum levels of mTORC1 and mTORC2 in psoriasis patients may indicate increased intracellular activation of these signaling molecules.
- Targeting both mTOR complexes with inhibitory agents could represent a promising therapeutic strategy for psoriasis treatment.
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