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Patch Testing in Solid Organ Transplant Recipients: Experience From a Tertiary Medical Center Over 13 Years
Katherine L Wang1, Leila M Tolaymat2, Mark D P Davis3
1From the Mayo Clinic Alix School of Medicine, Mayo Clinic, Jacksonville, Florida, USA.
Dermatitis : Contact, Atopic, Occupational, Drug
|December 9, 2024
Summary
Solid organ transplant recipients can experience allergic reactions during patch testing, even while on immunosuppressive therapy. However, results may be less reliable due to suppressed immune responses, potentially leading to false negatives.
Area of Science:
- Dermatology
- Immunology
- Transplant Medicine
Background:
- Immunosuppressive medications may interfere with patch testing by suppressing delayed-type hypersensitivity reactions.
- Limited research exists on patch testing outcomes in organ transplant recipients.
Purpose of the Study:
- To evaluate patch testing results in patients who have received solid organ transplants.
- To analyze a 13-year dataset of patch test outcomes in transplant recipients.
Main Methods:
- Retrospective analysis of adult transplant recipients undergoing patch testing.
- Data extraction from a clinical patch test database and subsequent chart review.
Main Results:
- Eighteen patients (kidney, liver, heart transplants) were analyzed.
- 38.9% of patients exhibited at least one positive patch test reaction.
- Common allergens included methylisothiazolinone, methyldibromo glutaronitrile, and benzalkonium chloride.
Conclusions:
- Allergic reactions were observed in liver and kidney transplant recipients during patch testing.
- Patch testing may still be beneficial for transplant patients on immunosuppressants.
- Immunosuppression can potentially cause false-negative patch test results.
