Comparative Evaluation of Low-level Laser Therapy and Intralesional Injection in OSMF Patients: A Quasi-randomized
Anwesha Pattnayak1, Asutosh Das2, Priyanka Rana3
1Department of Oral and Maxillofacial Surgery, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India, Phone: +91 7077027413,
The Journal of Contemporary Dental Practice
|December 9, 2024
Summary
Intralesional injections are more effective than low-level laser therapy (LLLT) for treating oral submucous fibrosis (OSMF). This study found significant improvements in mouth opening and reduced burning sensation with injections compared to LLLT.
Area of Science:
- Oral medicine
- Dental research
- Therapeutic interventions
Background:
- Oral submucous fibrosis (OSMF) is a chronic, potentially malignant disorder characterized by juxtaepithelial inflammatory reaction and fibrosis.
- Limited treatment options exist for OSMF, necessitating comparative studies of available therapies.
Purpose of the Study:
- To compare the efficacy of intralesional injections versus low-level laser therapy (LLLT) in managing grade II OSMF.
- To evaluate the impact of these treatments on symptoms like burning sensation and mouth opening.
Main Methods:
- A quasi-randomized trial involving 52 grade II OSMF patients (aged 20-60 years).
- Patients were divided into two groups: Group I received intralesional injections (hyaluronidase and dexamethasone), and Group II received LLLT.
- Outcomes including mouth opening and burning sensation were assessed at baseline and on days 3, 7, and 15.
Main Results:
- Intralesional injections significantly reduced burning sensation (from 4.00 to 1.19) and improved mouth opening (from 21.73 to 32.53) compared to LLLT.
- LLLT showed a reduction in burning sensation (from 4.15 to 2.65) and an increase in mouth opening (from 22.70 to 24.50).
- Statistically significant differences were observed between the treatment groups.
Conclusions:
- Intralesional injections demonstrated superior effectiveness in treating grade II OSMF compared to LLLT.
- Intralesional corticosteroid injections with hyaluronidase offer a promising therapeutic modality for OSMF management.
