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Basophil Activation Test for Allergy Diagnosis
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Urticaria.

Moshe Ben-Shoshan1, Amin Kanani2, Chrystyna Kalicinsky3

  • 1Division of Pediatric Allergy, Clinical Immunology and Dermatology, Department of Pediatrics, McGill University Health Center, Montreal, QC, Canada. moshebenshoshan@gmail.com.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|December 9, 2024
PubMed
Summary
This summary is machine-generated.

Urticaria (hives) and angioedema (swelling) are common skin conditions. Treatment primarily involves antihistamines, with omalizumab as a second-line option for chronic cases.

Keywords:
Acute urticariaChronic spontaneous urticariaChronic urticariaInducible urticariaUrticaria

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Area of Science:

  • Dermatology
  • Immunology
  • Allergy

Background:

  • Urticaria, commonly known as hives, is a prevalent skin condition.
  • It can occur with or without angioedema, which is deep skin swelling.
  • Urticaria is categorized as acute or chronic, with chronic forms further classified as spontaneous or inducible.

Purpose of the Study:

  • To provide a comprehensive review of urticaria and angioedema.
  • To discuss the etiology, diagnostic approaches, and management strategies.
  • To highlight current therapeutic mainstays and second-line treatments.

Main Methods:

  • Literature review of urticaria and angioedema.
  • Analysis of current treatment guidelines and pharmacological options.
  • Synthesis of information on diagnosis and management.

Main Results:

  • Second-generation, non-sedating histamine type 1 (H1)-receptor antihistamines are the primary treatment for acute and chronic urticaria.
  • Omalizumab, a monoclonal anti-immunoglobulin E (IgE) antibody, is a key second-line therapy for chronic, refractory urticaria.
  • The review covers causes, diagnosis, and management of urticaria with or without angioedema.

Conclusions:

  • Antihistamines are the first-line treatment for urticaria.
  • Omalizumab offers an effective option for managing severe chronic urticaria.
  • Effective management requires accurate diagnosis and tailored therapeutic approaches.