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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Accessory Structures of the Skin: Sebaceous Glands01:21

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Allergic Reactions02:06

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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Atopic dermatitis.

Stuart Carr1, Rebecca Pratt2, Fred White3

  • 1Snö Asthma & Allergy, Abu Dhabi, United Arab Emirates. stuart.carr@snoclinics.com.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|December 9, 2024
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis (AD) is a chronic skin condition impacting quality of life. Newer treatments like JAK inhibitors and biologics offer improved safety and efficacy for managing AD symptoms and improving patient outcomes.

Keywords:
Atopic dermatitisBiologicsDiagnosis and managementEmollientsJAK inhibitorsPhosphodiesterase-4 inhibitorsSkin care practicesTopical calcineurin inhibitorsTopical corticosteroids

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Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Atopic dermatitis (AD) is a prevalent chronic skin disorder significantly affecting patient quality of life (QoL).
  • Its pathogenesis involves a complex interaction of skin barrier defects, environmental factors, and immune system dysregulation.
  • Diagnosis relies on clinical criteria as specific diagnostic tests are unavailable.

Purpose of the Study:

  • To provide a comprehensive overview of atopic dermatitis (AD) management.
  • To discuss current and emerging therapeutic strategies for AD.
  • To highlight the impact of AD on patient QoL and the benefits of new treatments.

Main Methods:

  • Review of current literature on AD pathogenesis, diagnosis, and treatment.
  • Analysis of the efficacy and safety profiles of various therapeutic agents.
  • Discussion of the role of newer systemic agents (JAK inhibitors, biologics) versus traditional therapies.

Main Results:

  • Successful AD management requires a multifaceted approach including education, skin care, and pharmacologic treatments.
  • Topical corticosteroids are first-line treatments and may aid in prophylaxis.
  • Newer systemic agents, including Janus Kinase (JAK) inhibitors and biologics, demonstrate improved safety and efficacy over older immunosuppressives.

Conclusions:

  • While prognosis is generally favorable, severe AD with comorbidities can lead to poorer outcomes.
  • Newly approved systemic agents significantly enhance QoL for patients with moderate to severe AD.
  • Continued research into AD pathogenesis and treatment is crucial for improving patient care.