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Causal association between depression and constipation: A bidirectional two-sample Mendelian randomization study.

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This study found a causal link between depression and constipation using Mendelian randomization. Depression may cause constipation, but constipation does not appear to cause depression.

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Area of Science:

  • Psychiatry and Gastroenterology
  • Genetic Epidemiology

Background:

  • The causal relationship between depression and constipation remains under-researched.
  • Bidirectional causality requires robust investigation.

Purpose of the Study:

  • To investigate the causal relationship between depression and constipation using bidirectional two-sample Mendelian randomization (MR).
  • To provide evidence for depression influencing constipation and vice versa.

Main Methods:

  • Utilized two-sample Mendelian randomization (MR) analysis.
  • Extracted genetic data from independent depression (Finngen) and constipation (IEU OPEN) cohorts.
  • Employed inverse variance weighted (IVW), MR-Egger, and weighted median methods, alongside pleiotropy and heterogeneity tests.

Main Results:

  • A significant causal effect of depression on constipation was identified (OR = 1.005, P = 1.26 × 10⁻⁵).
  • No significant causal effect of constipation on depression was found (P = 0.389).
  • Analysis indicated no heterogeneity or horizontal pleiotropy for depression's effect on constipation, but heterogeneity was present for constipation's effect on depression.

Conclusions:

  • Depression is causally linked to constipation.
  • Findings suggest potential clinical implications for managing constipation in depressed patients.