A Retrospective Study to Investigate the Relationship Between Body Mass Index and Hemodynamic Characteristics in
Wenqi Xiao1, Ping Han1, Liping Song1
1Department of Cardiology, Beijing Haidian Hospital, Beijing, China.
Insights
Body Mass Index (BMI) significantly impacts hemodynamic profiles in hypertension. Higher BMI correlates with increased systemic vascular resistance index (SVRI) and decreased cardiac index (CI), suggesting BMI as a target for personalized hypertension treatment.
Area of Science:
- Cardiovascular Medicine
- Metabolic Disorders
- Hypertension Research
Background:
- The interplay between Body Mass Index (BMI) and hemodynamic regulation in hypertension remains incompletely understood.
- Hypertension is a complex condition influenced by various physiological factors, including metabolic status.
Purpose of the Study:
- To investigate the association between Body Mass Index (BMI) and hemodynamic parameters in a cohort of uncontrolled hypertensive patients.
- To identify how BMI influences cardiovascular regulation and phenotypes across different demographic groups.
Main Methods:
- Analysis of hemodynamic data (heart rate, cardiac index, arterial stiffness, systemic vascular resistance index, thoracic blood ratio) from 1368 hypertensive patients.
- Stratification of patients based on BMI (obese ≥ 28 kg/m², non-obese < 28 kg/m²) and analysis of phenotypic differences.
- Correlation analysis between BMI and key hemodynamic indicators across age and gender strata.
Main Results:
- Obese hypertensive patients exhibited distinct hemodynamic profiles, including increased heart rate and SVRI, and decreased cardiac index and arterial stiffness compared to non-obese counterparts.
- Specific phenotypes were observed: younger obese males showed peripheral vascular and volemic phenotypes, younger obese females displayed a cardiac phenotype, and older obese patients (both genders) had a higher prevalence of volemic phenotype.
- Body Mass Index demonstrated a significant inverse correlation with cardiac index and a positive correlation with systemic vascular resistance index across all subgroups.
Conclusions:
- Body Mass Index is a significant determinant of hemodynamic profiles in patients with hypertension.
- BMI influences cardiovascular regulation, contributing to diverse hemodynamic phenotypes in hypertensive individuals.
- Targeting BMI offers a promising avenue for developing personalized treatment strategies for hypertension.
Abstract:
The relationship between hemodynamic parameters and body mass index (BMI) in the context of blood pressure regulation in hypertension is unclear. Here, we analyzed data from 1368 uncontrolled hypertensive patients, including key hemodynamic indicators such as heart rate (HR), cardiac index (CI), arterial stiffness (AS), systemic vascular resistance index (SVRI), and thoracic blood ratio (TBR). In this cohort, the average BMI across all hypertension patients was 26.859 ± 3.897 (kg/m2), with obese patients (BMI ≥ 28 kg/m2) averaging 31.01 ± 2.87 kg/m2 and non-obese (BMI<28 kg/m2) averaging 24.70 ± 2.28 kg/m2. Younger obese patients exhibited higher diastolic pressures than non-obese peers (p < 0.01). Hemodynamic analysis showed obese patients had increased HR and SVRI but lower CI and AS (p < 0.01). Hypertensive males aged under 60 with obesity displayed a more prominent peripheral vascular phenotype (p < 0.05) and volemic phenotype (p < 0.01) than non-obese males. Obese females aged under 60 showed a higher incidence of cardiac phenotype (p < 0.01). Across genders, obese hypertensive patients aged over 60 had a greater prevalence of volemic phenotype than non-obese patients (p < 0.05, p < 0.01, respectively). BMI inversely correlated with CI and positively with SVRI across age and gender categories (p < 0.01). Taken together, we find that patients with hypertension exhibit diverse hemodynamic profiles, and BMI significantly correlates with hemodynamic parameters such as SVRI and CI. Our research identifies BMI as a valuable target for personalized hypertension treatment.
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