Jove
Visualize
Contact Us

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

219
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
219
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

479
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
479

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating stakeholder perspectives in the co-design of medical device software to monitor Parkinson's disease symptoms- A case-study.

MethodsX·2026
Same author

A degrader of HER2 and EGFR abolishes p95HER2 and shows robust antitumor efficacy in HER2-positive breast cancer.

Scientific reports·2026
Same author

Using Textural Analysis of Thermal Imaging to Predict Healing Status of Diabetes-Related Neuropathic Foot Ulcers: Protocol for a Co-Design and Longitudinal Study.

JMIR research protocols·2026
Same author

<i>RapidAI</i> Compared With Human Readers of Acute Stroke Imaging for Detection of Intracranial Vessel Occlusion.

Stroke (Hoboken, N.J.)·2026
Same author

Spectral Analysis for Detecting Infections in Diabetic Foot Wounds: A Non-Invasive Diagnostic Approach.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Pipeline to analyse Photoplethysmogram (PPG) Signal Quality.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 5, 2025

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

7.7K

Reflexive eye saccadic parameters in Parkinson's disease.

Nemuel D Pah1,2, Quoc C Ngo1, Nicole McConnell3

  • 1School of Engineering, RMIT University, Melbourne, VIC, Australia.

Frontiers in Medical Technology
|December 10, 2024
PubMed
Summary

People with Parkinson's disease (PwPD) exhibit distinct reflexive saccade patterns, including shorter latency and increased overshoot, compared to aged-matched controls (AMC). These eye-gaze differences, measurable with affordable technology, aid in early Parkinson's disease assessment.

Keywords:
Parkinson’s diseaseeye gazelatencyreflexive saccadesaccadic

More Related Videos

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram
06:12

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

Published on: March 13, 2018

10.6K
Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

7.4K

Related Experiment Videos

Last Updated: Jun 5, 2025

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

7.7K
Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram
06:12

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

Published on: March 13, 2018

10.6K
Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

7.4K

Area of Science:

  • Ophthalmology
  • Neurology
  • Biomedical Engineering

Background:

  • Abnormal reactive saccades, reduced saccadic gain, and impaired smooth pursuit are clinical markers for Parkinson's disease (PwPD).
  • Previous research shows inconsistent findings regarding saccade parameters like latency and transition times in PwPD.
  • Early-stage PwPD assessment requires refined methods to detect subtle oculomotor abnormalities.

Purpose of the Study:

  • To identify and compare reflexive saccade parameters between early-stage PwPD and age-matched controls (AMC).
  • To investigate differences in saccadic latency, overshoot, and eye-gaze fluctuations.
  • To explore the potential of eye-tracking technology for PwPD assessment.

Main Methods:

  • An observational study involving 70 participants (42 PwPD) and age-matched controls (AMC).
  • Reactive eye-gaze was recorded, and parameters of reflexive saccades and eye-gaze fluctuations were extracted.
  • Statistical analysis was performed using the Mann-Whitney U-test.

Main Results:

  • PwPD demonstrated significantly shorter latency for reflexive saccades away from the screen center compared to AMC.
  • PwPD exhibited a significantly higher saccade overshoot, indicating reduced accuracy in reaching targets.
  • PwPD showed increased horizontal and vertical eye-gaze fluctuations with a steady target; invalid saccade rates were similar between groups.

Conclusions:

  • Significant differences in reflexive saccade parameters exist between early-stage PwPD and AMC, detectable with inexpensive eye-tracking devices.
  • Consideration of invalid saccade trials and directional saccades (towards/away from center) may resolve previous study discrepancies.
  • These findings support the development of eye-tracking based tools for improved neurological assessment of Parkinson's disease.