The asymptomatic bacteriuria in the patients with epilepsy: A cross-sectional study
Yu-Shiue Chen1, Tzu-Ping Weng2,3, Ming-Chi Lai4
1Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Heliyon
|December 10, 2024
Summary
Asymptomatic bacteriuria (ASB) is more common in epilepsy patients, particularly females using oxcarbazepine. Lamotrigine may offer protection against ASB in epilepsy management.
Area of Science:
- Neurology
- Infectious Diseases
- Pharmacology
Background:
- Epilepsy is a neurological disorder marked by recurrent seizures.
- Urinary tract infections are a known concern with some anti-seizure drugs.
- Data on asymptomatic bacteriuria (ASB) in epilepsy is limited.
Purpose of the Study:
- To determine the prevalence of ASB in epilepsy patients.
- To identify risk factors associated with ASB in this population.
Main Methods:
- A cross-sectional study compared 200 epilepsy patients to 100 healthy controls.
- Urine analyses were performed during clinic follow-ups.
- Logistic regression analyzed epilepsy-related factors and ASB.
Main Results:
- ASB prevalence was higher in epilepsy patients (34.0%) versus controls (16.2%).
- Risk factors for ASB included female gender, proteinuria, and oxcarbazepine use.
- Lamotrigine showed a protective effect, as did older age.
Conclusions:
- ASB is more prevalent in individuals with epilepsy.
- Key risk factors include female sex, proteinuria, and oxcarbazepine.
- Lamotrigine may reduce ASB risk, highlighting the need for medication monitoring.
