The Western Denmark Myocardial Perfusion Imaging Registry: A Review and Validation Study

Area of Science:

• Cardiology
• Medical Imaging
• Health Informatics

Background:

• The Western Denmark Heart Registry (WDHR) established a sub-registry (WDHR-MPI) in 2017 for myocardial perfusion imaging (MPI) procedures.
• MPI utilizes single photon emission computed tomography and positron emission tomography.

Purpose of the Study:

• To evaluate the content, quality, and research utility of the WDHR-MPI.
• To assess the completeness and validity of key variables within the WDHR-MPI.

Main Methods:

• Procedure registration completeness was calculated against the Danish National Patient Registry (DNPR).
• Variable completeness was assessed by the proportion of non-missing values for 38 key variables.
• Data validity was determined using positive predictive values (PPV) and negative predictive values (NPV) from 300 patient records.

Main Results:

• 19,084 procedures in 17,871 patients were identified across seven cardiac centers.
• Overall procedure registration completeness increased from 14% in 2017 to 98% in 2021.
• Mean variable completeness was 89%, with high PPV (95%) and NPV (94%) for key variables.

Conclusions:

• The WDHR-MPI represents one of the largest systematic MPI cohorts.
• The registry demonstrates high data completeness and validity.
• These findings support the WDHR-MPI's significant potential for cardio-epidemiological research.