Opportunities, challenges and future perspectives of using bioinformatics and artificial intelligence techniques on...

Tropical diseases can often be caused by viruses, bacteria, parasites, and fungi. They can be spread over vectors. Analysis of multiple omics data types can be utilized in providing comprehensive insights into biological system functions and disease progression. To this end, bioinformatics tools and diverse AI techniques are pivotal in identifying and understanding tropical diseases through the analysis of omics data. In this article, we provide a thorough review of opportunities, challenges, and future directions of utilizing Bioinformatics tools and AI-assisted models on tropical disease identification using various omics data types. We conducted the review from 2015 to 2024 considering reliable databases of peer-reviewed journals and conference articles. Several keywords were taken for the article searching and around 40 articles were reviewed. According to the review, we observed that utilization of omics data with Bioinformatics tools like BLAST, and Clustal Omega can make significant outcomes in tropical disease identification. Further, the integration of multiple omics data improves biomarker identification, and disease predictions including disease outbreak predictions. Moreover, AI-assisted models can improve the precision, cost-effectiveness, and efficiency of CRISPR-based gene editing, optimizing gRNA design, and supporting advanced genetic correction. Several AI-assisted models including XAI can be used to identify diseases and repurpose therapeutic targets and biomarkers efficiently. Furthermore, recent advancements including Transformer-based models such as BERT and GPT-4, have been mainly applied for sequence analysis and functional genomics. Finally, the most recent GeneViT model, utilizing Vision Transformers, and other AI techniques like Generative Adversarial Networks, Federated Learning, Transfer Learning, Reinforcement Learning, Automated ML and Attention Mechanism have shown significant performance in disease classification using omics data.