Primary neuroendocrine tumor of the breast: A case report

Primary neuroendocrine neoplasm of the breast (PNENB) is a rare subtype of breast cancer, accounting for <1% of all breast tumors. The morphological features of PNENB are similar to those of neuroendocrine tumors originating in the lungs or gastrointestinal system, with tumor cells exhibiting the strong expression of neuroendocrine markers, including chromogranin A and synaptophysin. Since this type of cancer was first reported, the definition, classification and diagnostic criteria of PNENB have evolved and changed. However, accurate diagnostic criteria and standard treatment guidelines are lacking. The present report describes a specific case of PNENB, which was consistent with the morphological and molecular features of other cases in most previous studies. In addition, the current body of literature on PNENB, including its development, diagnosis, molecular features, treatment and prognosis is reviewed.