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Spatially Precise and Minimally Invasive Delivery of Peptides to the Spinal Cord for Behavior Modulation.

Tiffany W Leong¹, Zhenghong Gao², Eric T David³

¹Department of Bioengineering, University of Texas at Dallas, Richardson, Texas 75080, United States.

|December 10, 2024

Summary

Researchers developed a novel method to temporarily open the blood-spinal cord barrier (BSCB) using light-activated nanoparticles. This allows targeted delivery of therapeutic peptides into the spinal cord to modulate animal behavior with precision.

Keywords:

CNS drug delivery system behavior modulation blood−spinal cord barrier plasmonic nanoparticle ultrashort pulsed laser

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Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System

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Published on: October 29, 2019

Area of Science:

Neuroscience
Biomedical Engineering
Pharmacology

Background:

The blood-spinal cord barrier (BSCB) restricts molecular entry into the central nervous system.
Targeted delivery of therapeutics to the spinal cord is challenging due to the BSCB.
Modulating spinal cord function requires precise delivery methods.

Purpose of the Study:

To develop a minimally invasive method for transiently modulating BSCB permeability.
To achieve localized delivery of peptides into the spinal cord for behavior modulation.
To enable therapeutic interventions in the spinal cord without genetic modification.

Main Methods:

Utilized vasculature-targeted nanoparticles activated by optical stimulation.
Employed minimally invasive optical fiber for light delivery into the spinal cord.
Demonstrated BSCB permeability modulation in the lumbar region of mice.

Main Results:

Successfully delivered BSCB-impermeable peptides, including bombesin, into the spinal cord.
Induced rapid and transient itching behaviors in mice via bombesin delivery.
Showcased high spatial resolution for localized delivery and behavior modulation.
Confirmed no significant glial activation or impact on locomotor behavior.

Conclusions:

The developed approach enables precise, transient modulation of BSCB permeability.
This method facilitates targeted delivery of biologics for spinal cord therapies.
Offers a promising, non-genetic strategy for spatiotemporal control of spinal cord function and behavior.