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Updated: Jun 5, 2025
A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
Clinical application and progress in preoxygenation techniques
Chunling Yan1, Xiaolu Sun1, Yanxia Sun1
1Department of Anesthesia, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Introduction:
Airway management is often a life-saving procedure for patients. However, during airway management, difficult ventilation and difficult intubation are not always predictable. Preoxygenation, a crucial technique to improve oxygen reserves, plays a vital role in preventing hypoxemia during anesthesia induction. Preoxygenation technology and equipment are not monolithic. With the development of preoxygenation equipment and technology, the effect of preoxygenation has been improved, and it can be applied to different clinical settings.
Evidence Acquisition:
We conducted a literature search (PubMed and Scopus) in October 2023 with a starting date of January 1985, repeated in August 2024, to identify relevant articles. Key search terms included: 'preoxygenation,' 'high-flow nasal oxygenation,' 'non-invasive ventilation,' 'obese patients,' 'pediatric patients,' and 'elderly patients.'
Evidence Synthesis:
The abstracts of identified articles were assessed for relevance, along with screening of their references for further relevant publications. A full-text review of 219 articles was undertaken, of which 77 were included in the final review.
Conclusions:
Preoxygenation is really effective, and different preoxygenation equipment and technology can be applied in different clinical settings to improve the oxygen reserve of patients, thereby ensuring patient safety and improving patient outcome.
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