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Gastrointestinal quality of life in children born with gastroschisis

Matilda Bräutigam1, Michaela Dellenmark-Blom2, Kate Abrahamsson2

  • 1Department of Pediatric Surgery, Queen Silvia Children's Hospital, Sahlgrenska University, Hospital, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, 416 85, Gothenburg, Sweden. matilda.brautigam@gu.se.

Pediatric Surgery International
|December 10, 2024
PubMed

Insights

Children born with gastroschisis (GS) experience reduced gastrointestinal quality of life (GI-QoL), comparable to esophageal atresia (EA) but not Hirschsprung

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Quality of Life Research

Background:

  • Gastroschisis (GS) is a congenital condition requiring surgical intervention.
  • Long-term outcomes, particularly gastrointestinal quality of life (GI-QoL), are crucial for affected children.
  • Understanding GI-QoL in GS survivors informs follow-up care and management strategies.

Purpose of the Study:

  • To assess the gastrointestinal quality of life (GI-QoL) in children born with gastroschisis (GS).
  • To compare GI-QoL in GS patients with normative data from other pediatric gastrointestinal conditions.

Main Methods:

  • A cohort of 58 children (aged 2-18 years) operated for GS participated.
  • The Swedish PedsQL™ gastrointestinal symptoms module was used to evaluate GI-QoL.
  • Parent and child self-reports were collected and compared with Hirschsprung's disease (HD), esophageal atresia (EA), and functional constipation (FC) data.

Main Results:

  • Children with GS reported significantly lower scores for "Gas and bloating" compared to children with EA.
  • GI-QoL scores in GS patients were similar to EA patients across several scales.
  • GS patients showed better GI-QoL than HD and FC patients on most scales.
  • Clinical factors like "Days in ventilator" and "Days with Silo and Patch" correlated with worse GI-QoL.

Conclusions:

  • Gastroschisis significantly impacts GI-QoL in children, with effects comparable to esophageal atresia.
  • The GI-QoL in GS is generally better than in Hirschsprung's disease or functional constipation.
  • Clinical factors associated with GS severity highlight the need for tailored follow-up programs.
Abstract

Keywords:
Gastrointestinal quality of lifeGastroschisisPedsQL gastrointestinal symptom moduleQuality of lifeSilo

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