Association Between Peripheral Blood Regulatory T Cell Content with Inflammatory Stress Response and Immune Response...

Area of Science:

• Immunology
• Pediatric Sepsis Research
• Inflammatory Response

Background:

• Sepsis is a life-threatening condition characterized by dysregulated immune responses.
• Regulatory T (Treg) cells are crucial for maintaining immune homeostasis.
• The role of Treg cells in pediatric sepsis remains incompletely understood.

Purpose of the Study:

• To investigate the correlation between Regulatory T (Treg) cell levels and inflammatory stress response in pediatric sepsis patients.
• To analyze the relationship between Treg cells and immune response indicators in sepsis.
• To compare Treg cell content and related biomarkers between sepsis patients and healthy children.

Main Methods:

• Comparative analysis of Treg cell content, inflammatory mediators (TNF-α, IL-1β, IL-6, PCT, hs-CRP), and immunoglobulins (IgA, IgM, IgG) in 60 sepsis patients and 80 healthy children.
• Pearson correlation analysis to determine the relationship between Treg cell levels and inflammatory/immune markers.

Main Results:

• Sepsis patients exhibited significantly higher Treg cell content compared to healthy controls (P < 0.05).
• Elevated levels of inflammatory mediators (TNF-α, IL-1β, IL-6, PCT, hs-CRP) were observed in sepsis patients (P < 0.05).
• Peripheral blood Treg cell content positively correlated with inflammatory mediators and negatively correlated with immunoglobulin levels (IgA, IgM, IgG) in sepsis patients.

Conclusions:

• Increased Treg cell levels in pediatric sepsis are associated with heightened inflammatory responses.
• Treg cell modulation directly impacts the inflammatory stress and immune function during sepsis.
• Findings highlight the potential role of Treg cells as biomarkers or therapeutic targets in pediatric sepsis.