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Updated: Jun 5, 2025
Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation
Published on: November 26, 2019
Cross-species real-time detection of trends in pupil size fluctuation
Sharif I Kronemer1, Victoria E Gobo2, Catherine R Walsh2
1Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), NIHBC 10 - Clinical Center BG RM 1D80, 10 Center Dr., Bethesda, MD, 20892, USA. sharif.kronemer@nih.gov.
Abstract:
Pupillometry is a popular method because pupil size is easily measured and sensitive to central neural activity linked to behavior, cognition, emotion, and perception. Currently, there is no method for online monitoring phases of pupil size fluctuation. We introduce rtPupilPhase-an open-source software that automatically detects trends in pupil size in real time. This tool enables novel applications of real-time pupillometry for achieving numerous research and translational goals. We validated the performance of rtPupilPhase on human, rodent, and monkey pupil data, and we propose future implementations of real-time pupillometry.
