Ensembl 2025

Area of Science:

• Genomics
• Bioinformatics
• Comparative Genomics

Background:

• Ensembl is a comprehensive genomics data integration platform.
• It focuses on eukaryotic species relevant to human health, agriculture, and biodiversity.
• The platform provides access to a vast amount of genomic data.

Purpose of the Study:

• To report on the recent expansion and development of the Ensembl platform.
• To introduce the new, integrated Ensembl beta site.
• To highlight improvements in data annotation and tool development.

Main Methods:

• Integration of publicly available genomics data.
• Development of new genome browsers and data visualization tools.
• Expansion of annotation datasets for regulatory elements and genetic variations.

Main Results:

• Over 4800 eukaryotic and 31,300 prokaryotic genomes are now available.
• The new Ensembl beta site hosts over 2700 eukaryotic genome assemblies.
• Enhanced regulatory annotation and expanded Variant Effect Predictor tool are available.

Conclusions:

• The Ensembl platform continues to grow, offering a more integrated and comprehensive resource.
• The new beta site represents a significant step towards a unified Ensembl experience.
• Ongoing development enhances Ensembl's utility for diverse genomic research applications.