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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
RACE - Rapid Amplification of cDNA Ends02:35

RACE - Rapid Amplification of cDNA Ends

Rapid Amplification of cDNA Ends, or RACE, is one of the most effective methods to obtain a full-length cDNA from an mRNA sequence between a known internal region to the unknown sequence at the 5’ or 3’ end. The unknown region is cloned in the cDNA by a gene-specific primer that binds the known end, and a hybrid primer that attaches a predefined anchor sequence to the unknown end of the cDNA. The sequence in between is amplified by PCR with an anchor primer and a gene-specific primer.
Since the...
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze the...
Electro-mechanical Systems01:19

Electro-mechanical Systems

Electromechanical systems are intricate configurations that effectively combine electrical and mechanical elements to achieve a desired outcome. Central to many of these systems is the DC motor, a device that converts electrical energy into mechanical motion, enabling various applications ranging from simple fans to complex robotic mechanisms.
A key component of the DC motor is the armature, a rotating circuit positioned within a magnetic field. As an electric current passes through the...

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Pattern-based Search of Epigenomic Data Using GeNemo
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Ensembl 2025.

Sarah C Dyer1, Olanrewaju Austine-Orimoloye1, Andrey G Azov1

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

Nucleic Acids Research
|December 10, 2024
PubMed
Summary
This summary is machine-generated.

Ensembl, a genomics database, has expanded its species representation and launched a new beta site with integrated views. This platform supports research in human health, agriculture, and biodiversity.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Comparative Genomics

Background:

  • Ensembl is a comprehensive genomics data integration platform.
  • It focuses on eukaryotic species relevant to human health, agriculture, and biodiversity.
  • The platform provides access to a vast amount of genomic data.

Purpose of the Study:

  • To report on the recent expansion and development of the Ensembl platform.
  • To introduce the new, integrated Ensembl beta site.
  • To highlight improvements in data annotation and tool development.

Main Methods:

  • Integration of publicly available genomics data.
  • Development of new genome browsers and data visualization tools.
  • Expansion of annotation datasets for regulatory elements and genetic variations.

Main Results:

  • Over 4800 eukaryotic and 31,300 prokaryotic genomes are now available.
  • The new Ensembl beta site hosts over 2700 eukaryotic genome assemblies.
  • Enhanced regulatory annotation and expanded Variant Effect Predictor tool are available.

Conclusions:

  • The Ensembl platform continues to grow, offering a more integrated and comprehensive resource.
  • The new beta site represents a significant step towards a unified Ensembl experience.
  • Ongoing development enhances Ensembl's utility for diverse genomic research applications.