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Updated: Jun 5, 2025

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
Revealed at last: Structure of the antibody-receptor complex common to all IgE-mediated allergic hypersensitivity
1Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK.
Abstract:
Immunoglobulin E (IgE) binds with high affinity to its receptor, FcεRI, on mast cells and basophils, and cross-linking of allergen-specific IgE by minute amounts of multivalent allergen stimulates a powerful and immediate allergic reaction. In this issue of Science Signaling, Zhang et al. report the three-dimensional structures of the human and murine receptors, with and without bound IgE-Fc, to reveal some intriguing differences between mouse and human in this critical antibody-receptor interaction.
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