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Updated: Jul 23, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Digital microfluidics with integrated Raman sensor for high-sensitivity in-situ bioanalysis.

Wenbo Dong¹, Rongxin Fu², Nan Zhang³

¹Beijing Advanced Innovation Center for Intelligent Robots and Systems, School of Mechanical Engineering, Beijing Institute of Technology, Beijing, 100081, PR China.

Biosensors & Bioelectronics

|December 10, 2024

Summary

This study presents a novel digital microfluidics and Raman spectroscopy platform for efficient bioanalysis. The system automates sample preparation and in-situ analysis, reducing sample volume and contamination risks.

Keywords:

Digital microfluidics Exosome detection In-situ bioanalysis Optofuidics Raman spectroscopy

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Last Updated: Jul 23, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

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Published on: October 15, 2013

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

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Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Area of Science:

Bioanalytical Chemistry
Spectroscopy
Microfluidics

Background:

Traditional bioanalysis faces challenges with sample contamination, reagent consumption, and manual handling.
Digital microfluidics (DMF) offers potential for automated liquid handling.
Raman spectroscopy provides sensitive molecular detection but requires efficient sample preparation.

Purpose of the Study:

To develop an integrated bioanalytical platform combining DMF and Raman spectroscopy.
To automate sample preparation and in-situ analysis on a single device.
To enhance detection sensitivity and reduce sample/reagent requirements.

Main Methods:

Integration of a Translucent Raman Enhancement Stack (TRES) sensor with DMF.
Automated droplet-driving functionality for sample processing.
On-device enrichment and analysis of exosomes from serum samples.

Main Results:

The platform utilizes <5 μL of samples and reagents.
Achieved high sensitivity, excellent linearity, and effective detection of biochemical analytes.
Demonstrated successful on-device enrichment and analysis of exosomes.

Conclusions:

The developed platform streamlines bioanalysis through automation and integration.
The TRES sensor enhances Raman scattering signals for improved detection.
The system enables accurate, real-time, on-site analysis of complex biological samples.