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Updated: Jul 17, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Chitosan/polyvinyl alcohol-based magnetic hydrogel microspheres with controlled retention and regulated drug release
Peinan Yin1, Chengxiong Wei1, Anamaria Brozovic2
1State Key Laboratory of Structural Analysis, Optimization and CAE Software for Industrial Equipment, School of Mechanics and Aerospace Engineering, Dalian University of Technology, Dalian 116024, China.
Abstract:
As a clinically effective treatment for bladder cancer (BC), intravesical instillation still suffers from the debilitating efficacy triggered by frequent urination. Herein, the magnetic hydrogel microspheres (DOX-mMSs) with the incorporation of magnetic nanoparticles (MNPs) and doxorubicin (DOX) into polyvinyl alcohol (PVA)/chitosan (CS) are developed for intravesical instillation. The magnetic force initiated by the applied magnetic field (AMF) enables the long-term retention of DOX-mMSs in the bladder, and the convenient injection and excretion from the bladder can be accomplished in virtue of the micron size of the DOX-mMSs. Additionally, the pH-sensitive dissociation of CS and hydrazone bonds via which DOX is loaded into DOX-mMSs endows the possibility of controlled drug release by tuning the pH of the urine in the bladder. This dual control strategy is promising in intravesical treatment.
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