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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Chronic Kidney Disease and Thyroid Hormones.

Yuan Cheng1, Haofei Hu1, Wangyang Li1

  • 1Department of Nephrology, The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, China.

The Journal of Clinical Endocrinology and Metabolism
|December 10, 2024
PubMed
Summary
This summary is machine-generated.

Thyroid dysfunction in chronic kidney disease (CKD) patients accelerates kidney failure and increases mortality. Thyroid hormone replacement therapy (THRT) may reduce renal failure risk in hypothyroid CKD patients.

Keywords:
all-cause mortalitychronic kidney diseaserenal failurethyroid hormone replacement therapythyroid hormones

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Area of Science:

  • Nephrology
  • Endocrinology
  • Internal Medicine

Background:

  • Thyroid dysfunction is common in chronic kidney disease (CKD) patients.
  • Thyroid dysfunction significantly affects renal outcomes and patient mortality.
  • Investigating thyroid function's impact on CKD progression and mortality is crucial.

Purpose of the Study:

  • To examine the association between thyroid function and clinical outcomes in CKD patients.
  • To evaluate the therapeutic efficacy of thyroid hormone replacement therapy (THRT) in CKD patients.
  • To understand the role of thyroid health in managing chronic kidney disease.

Main Methods:

  • Retrospective cohort study utilizing the China Renal Data System.
  • Primary endpoints included composite renal failure and all-cause mortality.
  • Multivariable Cox regression and Kaplan-Meier analyses were employed for outcome assessment.

Main Results:

  • Hypothyroidism was linked to an increased risk of renal failure (aHR=1.29).
  • Both hypothyroidism (aHR=1.24) and hyperthyroidism (aHR=1.20) were associated with higher all-cause mortality.
  • THRT demonstrated a significant reduction in renal failure risk among hypothyroid patients (aHR=0.65).

Conclusions:

  • Hypothyroidism accelerates CKD progression, and both hypo- and hyperthyroidism elevate mortality risk.
  • THRT may mitigate the negative effects of hypothyroidism on kidney function.
  • Routine thyroid function monitoring and timely THRT are recommended for CKD management.