Grain actives modulate gut microbiota to improve obesity-related metabolic diseases: A review

Whole grain diet is considered to be related to the improvement of obesity, dyslipidemia, hypertension, hyperglycemia, diabetes, and other metabolic diseases. Many studies indicate that these active ingredients in grains can act as prebiotics to improve intestinal integrity and host metabolism, preventing obesity. In this review, the physiological role of gut microbiota (GM) in the human body and its relationship with obesity were first introduced. Subsequently, the interaction between naturally derived bioactive ingredients in grains and GM was discussed, and the research progress of different grains was made in improving obesity and related metabolic diseases by regulating GM. This article provides fundamental explanations for the regulation of whole grains on obesity by GM and novel potential for the development of whole grain functional foods.