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Reply to the Letter to the Editor 'Circulating tumor DNA after definitive therapy for locally advanced rectal cancer'

A Bercz1, J J Smith2, P B Romesser3

  • 1Department of Surgery, Colorectal Surgery Service, Memorial Sloan Kettering Cancer Center, New York, USA.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|December 10, 2024
PubMed
Abstract

No abstract available in PubMed .

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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