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Updated: Jun 5, 2025

A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1
Published on: March 18, 2017
Quadruplex DNA Hybrid Catalysts for Enantioselective Reactions
Zixiao Wang1, Xingchen Dong1, Yashao Chen1
1Key Laboratory of Applied Surface and Colloid Chemistry (MOE), School of Chemistry and Chemical Engineering, Shaanxi Normal University, 710119, Xi'an, China.
Abstract:
Beyond the pivotal genetic roles of DNA, its duplex structures as chiral scaffolds interacting with metal complexes give rise to DNA hybrid catalysts for a set of aqueous-phase enantioselective reactions. Besides DNA duplex, DNA quadruplexes including G-quadruplex and i-motif show tunable structures with variable non-canonical base pairs. In this concept, based on the interaction between metal species and DNA, we classify the construction strategies of quadruplex DNA hybrid catalysts into supramolecular, covalent and coordinative modes. Furthermore, we analyze the relationship between DNA quadruplexes and their enantioselective catalytic performance. Finally, we summarize the current challenges and look forward to the future directions in DNA-based enantioselective catalysis.
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