Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrons01:10

Nephrons

2.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.2K
Renal Corpuscle01:20

Renal Corpuscle

1.7K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.7K
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

63
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
63
Dialysis01:27

Dialysis

264
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
264
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

53
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
53
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

72
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
72

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Randomized Controlled Clinical Trial of Allogeneic Mesenchymal Stromal Cell Infusion in Diabetic Kidney Disease.

Kidney international reports·2026
Same author

'The Simpsons' Did It Again! Periodontitis and Tooth Loss Predict Mortality in Springfield: A Retrospective Cohort Study.

Journal of periodontal research·2026
Same author

The impact of multiple long-term conditions on mortality, progression to kidney failure and health-related quality of life among people with chronic kidney disease: a multicentre cohort study (NURTuRE-CKD).

Annals of medicine·2026
Same author

"They are nae worrying about it… so …what's the point in asking?": A qualitative study of candidacy for early CKD care in areas of multiple deprivation.

BMC nephrology·2026
Same author

Differential antimicrobial activity of two LL37 derivatives against periodontal bacteria, including enhanced efficacy against <i>P. gingivalis</i> in the presence of cigarette smoke.

Frontiers in microbiology·2026
Same author

Pancreatic Cancer in the Holobiont and Therapeutic Targets: A Review.

Journal of clinical medicine·2026

Related Experiment Video

Updated: Jun 5, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

11.3K

Interplay between periodontitis and chronic kidney disease.

Iain L C Chapple1,2, Josefine Hirschfeld3,4, Paul Cockwell5

  • 1Periodontal Research Group, Institute of Clinical Sciences, University of Birmingham and Birmingham Community Healthcare NHS Foundation Trust, Birmingham, UK. i.l.c.chapple@bham.ac.uk.

Nature Reviews. Nephrology
|December 10, 2024
PubMed
Summary

Periodontitis, a gum disease, significantly increases the risk of chronic kidney disease (CKD) and other non-communicable diseases. This link is bidirectional, suggesting new treatment approaches for both conditions.

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:37

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

98
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

489

Related Experiment Videos

Last Updated: Jun 5, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

11.3K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:37

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

98
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

489

Area of Science:

  • Oral Health
  • Inflammatory Diseases
  • Nephrology

Background:

  • Periodontitis is a prevalent, preventable inflammatory disease causing tooth loss.
  • It affects over 1 billion people globally and is linked to systemic non-communicable diseases (NCDs).
  • Periodontitis is associated with increased mortality and NCDs like cardiovascular disease, type 2 diabetes, and chronic kidney disease (CKD).

Purpose of the Study:

  • To investigate the association between periodontitis and NCDs, particularly CKD.
  • To explore periodontitis as a non-traditional risk factor for CKD.
  • To understand the bidirectional relationship between periodontitis and CKD.

Main Methods:

  • Review of existing literature on periodontitis and NCDs.
  • Analysis of the pathophysiological mechanisms linking oral inflammation to systemic disease.
  • Examination of the systemic inflammatory profile in periodontitis mirroring CKD.

Main Results:

  • Periodontitis is linked to a higher risk of NCDs, including CKD, independent of shared risk factors.
  • Systemic inflammation from periodontitis, characterized by immune cell and mediator leakage, resembles that in CKD patients.
  • The relationship between periodontitis and CKD appears bidirectional.

Conclusions:

  • Periodontitis is a significant risk factor for CKD and other NCDs.
  • The bidirectional link suggests a shared inflammatory pathway.
  • Further large-scale studies are needed to confirm causality and develop integrated care strategies.