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Main genetic entities associated with tooth agenesis
Francisco Cammarata-Scalisi1, Colin E Willoughby2, Jinia R El-Feghaly3
1Pediatric Service, Regional of Antofagasta Hospital, Antofagasta, Chile. francocammarata19@gmail.com.
Clinical Oral Investigations
|December 10, 2024
Summary
Tooth agenesis, the congenital absence of teeth, stems from disrupted early development. Key genetic syndromes, including ectodermal dysplasia, are linked to this condition, impacting function and appearance.
Area of Science:
- Developmental Biology
- Genetics
- Oral Medicine
Background:
- Tooth agenesis is the congenital absence of one or more teeth.
- It arises from disrupted ectodermal-mesenchymal interactions during tooth development.
Purpose of the Study:
- To review genetic syndromes associated with tooth agenesis.
- To highlight the multifactorial etiology of tooth agenesis.
Main Methods:
- A narrative literature review was conducted.
- Focused on identifying genetic syndromes linked to tooth agenesis.
Main Results:
- Tooth agenesis etiology is multifactorial: genetic, epigenetic, and environmental.
- Associated syndromes include chromosomal alterations, ectodermal dysplasia, Axenfeld-Rieger syndrome, oral-facial clefts, and cancer predisposition syndromes.
Conclusions:
- Tooth agenesis can cause masticatory dysfunction, disfigurement, and psychological issues.
- Early diagnosis is vital for patient management and genetic counseling.
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