Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatic reactions to nifedipine.

M Abramson, G O Littlejohn

    The Medical Journal of Australia
    |January 7, 1985
    PubMed
    Summary

    Nifedipine use can cause abnormal liver function tests. Drug withdrawal led to normalization, suggesting a hypersensitivity reaction to nifedipine.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Fibromyalgia onset has a high impact on work ability in Australians.

    Internal medicine journal·2016
    Same author

    Use of hardware modified phones for exposure assessment in health studies in Australia: verification of compliance with standards.

    Australasian physical & engineering sciences in medicine·2009
    Same author

    Do levels of airborne grass pollen influence asthma hospital admissions?

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2007
    Same author

    Occupational asthma.

    Thorax·2006
    Same author

    Encasement of bedding does not improve asthma in atopic adult asthmatics.

    International archives of allergy and immunology·2005
    Same author

    Asthma and vaccination history in a young adult cohort.

    Australian and New Zealand journal of public health·2005

    Area of Science:

    • Pharmacology
    • Hepatology
    • Clinical Toxicology

    Background:

    • Nifedipine is a widely used calcium channel blocker for cardiovascular conditions.
    • Adverse drug reactions require thorough investigation to ensure patient safety.
    • Liver function monitoring is crucial during pharmacotherapy.

    Observation:

    • Two patients presented with elevated liver function tests during nifedipine treatment.
    • Hepatotoxicity was suspected as the cause of abnormal liver enzymes.
    • Cessation of nifedipine therapy resulted in the resolution of liver abnormalities.

    Findings:

    • The reported cases indicate a potential link between nifedipine and drug-induced liver injury.
    • Hypersensitivity is proposed as the underlying mechanism for nifedipine hepatotoxicity.
    • This suggests an idiosyncratic immune response to the medication.

    Implications:

    • Clinicians should consider nifedipine as a potential cause of abnormal liver function tests.
    • Patient history and drug withdrawal are key diagnostic tools for drug-induced liver injury.
    • Further research into nifedipine hypersensitivity may inform safer prescribing practices.

    Related Experiment Videos