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Imaging the Choroid Plexus.

Niels Bergsland1, Michael G Dwyer1, Robert Zivadinov2

  • 1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|December 11, 2024
PubMed
Summary
This summary is machine-generated.

The choroid plexus (CP) plays a key role in multiple sclerosis (MS) by influencing inflammation and immune cell movement. Further research into the CP could reveal new therapeutic targets for MS.

Keywords:
Animal modelHistopathologyMRIMultiple sclerosischoroid plexus

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Area of Science:

  • Neuroscience
  • Immunology
  • Radiology

Background:

  • The choroid plexus (CP), once thought only to produce cerebrospinal fluid, is now recognized for its roles in brain immunosurveillance and immune cell trafficking.
  • Histopathology and animal studies reveal inflammatory cell accumulation and dynamic CP volume changes correlating with immune infiltration in multiple sclerosis (MS).

Purpose of the Study:

  • To investigate the evolving role of the choroid plexus (CP) in the pathophysiology of multiple sclerosis (MS).
  • To explore the CP as a potential therapeutic target for managing MS progression.

Main Methods:

  • Review of histopathology findings in donor tissue.
  • Corroboration with animal studies using immunohistopathology and magnetic resonance imaging (MRI).
  • In vivo MRI studies in individuals with MS to assess CP volume and inflammation over disease stages.

Main Results:

  • The CP is involved in immune cell trafficking and shows inflammatory changes in MS.
  • CP volume increases early in MS, and inflammation persists throughout the disease.
  • MRI studies demonstrate dynamic changes in CP volume linked to immune cell infiltration.

Conclusions:

  • The choroid plexus (CP) is implicated in multiple sclerosis (MS) pathophysiology, exhibiting inflammation and volume changes.
  • The CP's role extends beyond CSF production, encompassing immune surveillance and cell trafficking.
  • Further investigation of the CP, aided by advanced imaging, may identify novel therapeutic strategies for MS.