Advances in the generation of erythrocytes from stem cells in vitro

Red blood cell transfusion is the main treatment to improve anemia caused by many reasons and has important clinical application value. However, the supply of red blood cells at home and abroad is currently very tight. Therefore, the utilization of stem cells to prepare erythrocytes for clinical use is expected to become a new mode of blood supply and security in the future. This review describes the process of erythropoiesis regulation in vivo, summarizes the latest research progress of in vitro erythropoiesis, and points out the current challenges of in vitro erythropoiesis, which is expected to provide a new idea for solving the problem of insufficient clinical erythropoiesis supply.